EFFECT OF ORGANIC TEMPLATES ON NANOSIZED BIOMATERIAL (HYDROXYAPATITE, CA10(PO4)6(OH)2) SYNTHESIZED BY HYDROTHERMAL PROCESS USED FOR DRUG DELIVERY SYSTEM
Sumaira Naz, Shahid Khan Durrani, Qanita Tayyaba and Nazar Hussain
Materials Division, Directorate of Technology, PINSTECH, P. O. Nilore, Islamabad, Pakistan
Abstract:
Hydroxyapatite, CA10(PO4)6(OH)2 is the emerging most bioceramic, which is widely used in various biochemical applications, mainly in orthopedics and dentistry due to its close similarities with organic mineral component of bone and teeth. It is also used in drug delivery systems due to its high binding affinity for a large numbers of pharmacological substances such as antibiotics, enzymes, hormones, antibody fragments, steroids etc. Synthetic hydroxyapatite is known to be similar to naturally occurring hydroxyapatite on the basis of crystallographic and chemical studies.
Nanoparticles of hydroxyapatite (CA10(PO4)6(OH)2) were prepared synthetically by hydrothermal method using surfactants such as CTAB, Twin 80, SDS, PVA, TEAOH and TPABr as organic templates. Mixtures of precursors and surfactant were placed in autoclave for 3 h at 150ºC, which produces fine powder of hydroxyapatite. The products were characterized for phase analysis, thermal properties, structure composition, and structuremorphology by using XRD, TGA-DTA, FTIR and SEM. The XRD patterns revealed the formation of similar hydroxyapatite phase using different surfactants (CTAB, Twin 80, SDS, PVA, TEAOH and TPABr) at the same hydrothermal processing conditions. It is observed that organic templates (surfactants) affect the morphologies and nanosize of hydroxyapatite nanoparticles.
Keywords: Hydroxyapatite, Hydrothermal, nanoparticles, XRD, SEM.